Topic: episodic memory encoding

Although excitatory cells comprise the bulk of hippocampal neurons, roughly 20 percent of the neuronal population is inhibitory. While an increasing interest in inhibitory signaling has led to the discovery of its importance for controlling episodic memory encoding and consolidation, its contribution to the function of individual engram neurons is largely unknown. In this project, we study GABAergic inhibitory synaptic plasticity in hippocampal engram neurons and its function in memory precision. We employ the Fos-TRAP2 system to label and manipulate contextual fear memory engrams in mice. We