Reelin affects the lipid composition of the neuronal plasma membrane
Yuto Takekoshi, Hugo Ando, Takao Kohno, Makoto Arita, Mitsuharu Hattori · FENS Forum 2024
The neuronal plasma membrane is composed of versatile lipid molecules with distinct biophysical characteristics and functions. Among them, sphingomyelin (SM) influences the localization and functions of various proteins including GPI-anchored proteins. Therefore, elucidation of the mechanisms that regulate the SM amount is important for understanding the mechanisms that control neuronal morphology and information transmission. Reelin is a secreted protein that regulates neuronal morphology and dynamics. We previously found that the embryonic brain of Reelin-deficient mice shows aberrant lipid
ePoster · Neuroscience