Topic: ER alpha

Estrogen is a neurosteroid with protective and regenerative properties. Nerve growth factor differentiated PC12 neuronal cells have been shown to express both nuclear estrogen receptor ER alpha (genomic) and membrane estrogen receptor GPER (non-genomic), thus our aim is to differentiate which cellular pathways are employed by estrogen in neuritogenesis regulation. Here we treated such cells with 17-beta-Estradiol (E2) in a series of short and long incubation times. E2 treatments (10-6M) were compared with plasma membranous G protein-coupled estrogen receptor agonist G1 (10-6M) and antagonist G