ErbB inhibition rescues nigral dopamine neuron hyperactivity and repetitive behaviors in a mouse model of fragile X syndrome
Sebastian Luca D'Addario, Eleonora Rosina, Mariangela Massaro Cenere, Claudia Bagni, Nicola Biagio Mercuri, Ada Ledonne · FENS Forum 2024
Repetitive stereotyped behaviors are core symptoms of autism spectrum disorders (ASD) and fragile X syndrome (FXS), the prevalent genetic cause of intellectual disability and autism. The nigrostriatal dopamine (DA) circuit is key to movement control and creation of habits and sequential behaviors, thus its dysregulation could promote occurrence of autistic repetitive behaviors. However, specific evidence proving altered nigral DA neuron activity in ASD or FXS models is absent. In this study, by analyzing nigral DA neuron activity in adolescent Fmr1 KO mice by ex vivo electrophysiology we provi
ePoster · Neuroscience