NT3-TrkC signaling in the brain fear network underlies inter-individual differences in the formation and maintenance of contextual fear extinction memories
Gianluca Masella, Francisca Silva, Elisa Corti, Garikoitz Azkona, Maria Francisca Madeira, Ângelo R. Tomé, Samira G. Ferreira, Rodrigo A. Cunha, Carlos B. Duarte, Monica Santos · FENS Forum 2024
Anxiety disorders are among the most common mental disorders, having inappropriate learned fear and resistance to extinction as cardinal features. Exposure therapy represents a promising therapeutic approach, the efficiency of which depends on inter-individual variation in fear extinction learning. Previously we reported that the formation of fear memories is associated with a general downregulation of the tropomyosin receptor kinase C (TrkC) activation in the brain fear network. Particularly, inactivation of TrkC and of the downstream Erk1/2 signaling in the hippocampus is associated with the
ePoster · Neuroscience