Structural and functional analysis of ER-mitochondrial contact sites in PRKN-mutant patient dopaminergic neurons derived from tyrosine hydroxylase reporter iPSC lines
Masato Koike, Mutsumi Yokota, Yutaro Yoshimo, Hashimoto Ryota, Soichiro Kakuta, Kei-Ichi Ishikawa, Hideyuki Okano, Wado Akamatsu, Nobutaka Hattori · FENS Forum 2024
Endoplasmic reticulum-mitochondrial contact sites (ERMCS) play an important role in lipid metabolism, calcium signaling, and autophagy. Disruption of the ERMCS has been reported to be linked to several neurodegenerative diseases, including Alzheimer’s disease (AD), Parkinson’s disease (PD), and amyotrophic lateral sclerosis (ALS). However, the etiological role of ERMCS in these diseases remains unclear. We have previously established tyrosine hydroxylase reporter (TH-GFP) iPSC lines from a PD patient with a PRKN mutation for correlative light-electron microscopy (CLEM) analysis and live cell i
ePoster · Neuroscience