Topic: ESCRT proteins

As evidence for the NMDA receptor hypofunction theory of schizophrenia grows, more attention is being paid to restoring correct glutamatergic signalling as a therapy option leading to development of novel antipsychotics. The ESCRT proteins groups are involved in sorting ubiquitinated membrane receptors to lysosomes, which is a key method for reducing cell surface receptor signalling. The research illustrates the effect of knocking down and overexpression of TSG101 and VPS4a genes on the function of ESCRTs machinery and the expression of NMDA receptors. The average number of NMDA receptors on t