Topic: Estrogen (E2)

Increasing evidence have highlighted significant sex-related differences in animal physiology and behavior, both in health and disease. Despite that, most neuroscience research involving animal models is still conducted using males only. Estrogen (E2) is known to have a protective role in females, mainly by preventing inflammation, however, when hormone levels decline, females become more prone than males to metabolic, cardiovascular and psychiatric diseases. Thanks to our established conditional knockout mouse model (Npy1rrfb mice), in which the gene encoding for the main NPY receptor Y1 is s