ID2-ETS2 axis regulates the transcriptional acquisition of pro-tumoral microglia phenotype in glioma
Guillermo Vázquez Cabrera, Noémie Roncier, Farah Real Oualit, Martin Škandík, Mireia Cruz De Los Santos, Austeja Baleviciute, Mathilde Cheray, Bertrand Joseph · FENS Forum 2024
Glioblastoma is a highly aggressive brain tumour that creates an immunosuppressive microenvironment.Microglia, the brain's resident immune cells, play a crucial role in this environment. Glioblastoma cells canreprogram microglia to create a supportive niche that promotes tumour growth. However, the mechanismscontrolling the acquisition of a transcriptome-associated with a tumour-supportive microglial reactive state arenot fully understood. In this study, we investigated changes in the transcriptional profile of BV2 microgliaexposed to C6 glioma cells. RNA sequencing analysis revealed a signifi
ePoster · Neuroscience