A novel mouse model of light-mediated recanalization after stroke
Emilia Conti, Noemi Carlini, Antea Minetti, Marzia Baldereschi, Benedetta Piccardi, Cristina Spalletti, Cristina Sarti, Anna Letizia Allegra Mascaro, Francesco Saverio Pavone · FENS Forum 2024
Stroke is a leading cause of adult disability and the third leading cause of death. Despite expanding reperfusion treatment indications, a significant proportion of patients (54.5%) experience poor outcomes despite successful recanalization, emphasizing the need for a clinically relevant preclinical stroke model. In response, we developed a novel mouse model involving photothrombotic (PT) occlusion and light-induced recanalization of the distal branch of the middle cerebral artery (MCA), closely mimicking ischemic progression in clinical settings.The stable occlusion of the MCA's distal branch
ePoster · Neuroscience