Topic: Evans blue leakage

Insufficient evidence exists regarding the effect of nanoparticles, particularly liposomes loaded with a statin, on traumatic brain injury (TBI). We investigated the impact of atorvastatin-loaded PEG (polyethylene glycol) conjugated liposomes (LipoStatin) on outcomes in mice with TBI. PEGylated liposomes loaded with atorvastatin were developed as nanoparticles to specifically accumulate in the injury region and release the drug to lessen the harmful effects of TBI. TBI was induced using the Marmarou method, applying five consecutive head impacts at 12-hour intervals with a weight of 120 g for