Topic: excessive physical activity

Anorexia Nervosa (AN) is a multifactorial mental disorder characterized by voluntary food restriction and excessive physical activity leading to dramatic weight loss. The Brain-Derived Neurotropic Factor (BNDF) gene has been associated with AN. In rodents, both central and peripheral BDNF have been found to induce weight loss and anorexic effects. Thus, besides its function in neuronal development and mood, BDNF also acts as a metabolic regulator, making it a candidate biomarker for AN diagnosis. We used C57BL/6J female mice under 2-week 50% food restriction with access to running wheels to mi