Topic: excitatory granule cells

Hippocampal dentate gyrus (DG) is essential for encoding highly similar inputs into distinct neural representations. This function is mainly attributed to the sparsely firing excitatory granule cells. It is not known how excitatory DG neurons modify their firing patterns in response to different conditions, to facilitate learning. We studied the activity of excitatory DG neurons during discrimination fear conditioning task (FC) using in vivo one-photon calcium imaging in adult, healthy C57/black mice. We compared learning in males (n = 6) and females (n = 6) and further, in voluntarily running