Topic: excitatory/inhibitory (E/I) imbalance

Schizophrenia is a complex disorder known for its positive symptoms: delusions and hallucinations. However, the impact of schizophrenia on function is mostly due to its executive dysfunction. Mechanistically, it is known that the prefrontal cortex (PFC) is dysfunctional in this disorder and that there is a general excitatory/inhibitory (E/I) imbalance in the schizophrenia brain. However, whether schizophrenia executive dysfunction can be specifically attributed to prefrontal E/I imbalance is unknown. Here, through a series of experiments across schizophrenia-relevant mouse models, we show the