Topic: excitatory-inhibitory integration

Synaptic integration is crucial for inter-neuronal communication, and excitatory-inhibitory integration is utterly important in lateral superior olive (LSO) neurons, enabling sound localization. For this purpose, LSO neurons integrate excitatory inputs from the ipsilateral cochlear nucleus (CN) with inhibitory inputs from the medial nucleus of the trapezoid body (MNTB). The strength and number of excitatory and inhibitory inputs show notable differences. The convergence of multiple excitatory input fibers (~10‑40) is a source for synaptic noise in the spike driving inputs. We focused on how sy