Topic: excitatory projection neurons

The mammalian neocortex is populated by different neuronal and glia cell types. During development, excitatory projection neurons and certain glia lineages emerge from radial glial progenitors (RGP). Impairments in RGP progenitor behavior and lineage progression can affect neuron production and maturation, leading to cortical malformations such as micro- or macrocephaly. The Notch signaling pathway instructs stem cell self-renewal and differentiation in a variety of tissues, including the brain. The Notch1 receptor is expressed in RGPs during embryonic development and maintains the progenitor