Topic: Exendin-4

Alcohol use disorder (AUD) is a complex and severe neuropsychiatric disorder with high mortality and morbidity rates. Insight into the complex mechanisms that underlie alcohol-related responses would contribute toward novel treatment options for AUD. Glucagon-like peptide 1, a gut brain peptide that regulate appetite, has lately been suggested as such candidate. The GLP-1 receptor agonist, exendin-4 (Ex4), prevents alcohol-induced reward, alcohol intake, relapse drinking and the motivation to consume alcohol in rodents. However, the brain circuits that participate in the ability of GLP-1 to re