Targeting the AMPK pathway as a treatment strategy for Huntington’s disease
Balázs Kis, Varga Ágnes, Hühn Daniela, Barker Roger A., Fernández-Capetillo Óscar, Pircs Karolina · FENS Forum 2024
Age-related neurodegenerative diseases are becoming more prevalent as human lifespan increases. Modeling human aging is challenging in the lab. We use transdifferentiation via an all-in-one lentiviral vector to directly reprogram human donor-derived fibroblasts into induced neurons (iN). The advantage of this methodology is the maintaining of age and disease-related signatures of the donor cells as iNs bypass the intermediary cell rejuvenation.Huntington’s disease (HD) is an autosomal dominant age-related neurodegenerative disorder caused by a mutated Huntingtin (HTT) gene containing an expans
ePoster · Neuroscience