Density-based Neural Decoding using Spike Localization for Neuropixels Recordings
Yizi Zhang, Tianxiao He, Julien Boussard, Cole Hurwitz, Erdem Varol, Charlie Windolf, Olivier Winter, Matt Whiteway, The International Brain Lab The International Brain Lab, Liam Paninski · COSYNE 2023
Sun, Mar 12, 2023
Neural decoding is essential for understanding the association between neural activity and behavior. A prerequisite for most decoding methods is spike sorting, the assignment of action potentials (or spikes) to individual neurons. Current spike sorting algorithms, however, can be inaccurate and do not properly model uncertainty of spike assignments, therefore discarding information that could potentially improve decoding performance. Recent advances in high-channel-count probes like Neuropixels (NP) and extracellular analysis pipelines allow for extracting a rich set of spike features to direc