Extrastriatal dopamine differentially modulates erroneous perceptual confidence
Matthaeus Willeit, Irena Dajic, Ulrich Sauerzopf, Lukas Nics, Wolfgang Wadsak, Markus Mitterhauser, Cecile Philippe, Marcus Hacker, Chris Mathys, Chris Eisenegger, Nicole Praschak-Rieder, Nace Mikus, Ana Weidenauer · FENS Forum 2024
False percepts induced by sensory conditioning are a promising laboratory model for hallucinations and similar illusory phenomena, with links to both clinical symptoms and neurobiological features of psychosis. The aim of the present study was to investigate the relationship between extracellular dopamine levels, as quantified by the dopamine D2/3 receptor agonist ligand [11C]-(+)-PHNO, and confidence with which conditioned auditory percepts are reported.To this end, ten healthy volunteers (2m, 8f) completed a cross-modal sensory conditioning task after undergoing a bolus plus constant infusio
ePoster · Neuroscience