Topic: extracellular pH

Acid-sensing ion channel 1 (ASIC1) is a trimeric ion channel, opened by a fast drop of extracellular pH. ASIC1 is highly abundant in the CNS and present at the postsynapse. In slice recordings of the lateral amygdala, it was shown, that ASIC1 can be activated by protons co-released by transmitter exocytosis, thus contributing to synaptic transmission. Intriguingly, ASIC1-dependent current was small compared to currents of GABA or Glutamate receptors, however, ASIC1 was reported to have a significant impact on various physiological and pathophysiological processes e.g. fear related behavior, lo