Targeting the dysfunctional endocannabinoid system in Gulf War Illness
Kwang-Mook Jung, Erica Squire, Hye-Lim Lee, Daniele Piomelli, Vipan Parihar · FENS Forum 2024
An estimated one-third of American veterans of the 1991 Gulf War continue to experience multiple unexplained health problems known as Gulf War Illness (GWI). GWI is a chronic disorder that is characterized by persistent and heterogeneous symptoms including but not limited to anxiety, pain, fatigue, and cognitive impairment. In the current study, we hypothesized that exposure to toxic chemicals during the Gulf War (GW) may produce a long-lasting disruption in the endocannabinoid (ECB) system, one of the brain’s endogenous anti-inflammatory mechanisms, leading to dysregulated microglial activati
ePoster · Neuroscience