Topic: fear memory engrams

The interaction of the hippocampus and amygdala, crucial for the formation of emotional memories, may play a central role in the pathophysiology of posttraumatic stress disorder (PTSD). However, with amygdala hyperactivity regarded as a hallmark of PTSD, it is still not clear whether amygdala hyperresponsiveness before a traumatic event is a predisposing factor for the development of PTSD or is an acquired condition upon trauma. To address this question, in the current study, we explore the effect of heightened amygdala activity on anxiety and fear memory in the formation of hippocampal fear m