Explore the temporal advances of memory amplification mechanism and target to suppress its effect by potential pharmacological intervention
Ashutosh Ahire, Deborah Daphne, Iris Reuveni, Edi Barkai · FENS Forum 2024
Background:We recently reported experimental and theoretical evidence for a long-term mechanism that amplifies the response of a subset of neurons that were recruited during fear learning that was termed “memory amplification mechanism”. This mechanism is mediated CaMKII dependent twofold increase of the strength of all inhibitory and all excitatory synapses in the cell. The key function of the amplification mechanism is to promote an already-formed memory to a dominant memory.Aim:Using TRAP2 genetically modified mice, we investigated the long-term retention of traumatic memory through an ampl
ePoster · Neuroscience