The hippocampal CA3-CA1 circuit is critical for memory encoding and retrieval. Previous work has shown this feedforward excitatory-inhibitory network (FFEI) maintains a precise excitation-inhibition (E-I) balance onto CA1 pyramidal cells (CA1PCs) (Bhatia et al, 2019). However, how this balance dynamically evolves dependent of the history of sustained input activity is unclear. Deviations from E-I balance are important for gating, normalization, and representation of input ensembles. Using in vitro whole-cell recordings in mouse hippocampal slices, we probed E-I balance by optogenetically evok
ePoster · Neuroscience