The peptidergic control circuit for ovarian cycles
Lanxiang Li, Dejiao Xu, Jinfeng Huang, Weixin Qian, Miao Li, Feng Liang, Huiqin Zhou, Wei Lin, Ying-Ying Zou, Lei Li, Jin Bao, Robert K Naumann, Hong Wang · FENS Forum 2024
The female reproductive cycle is a fundamental physiological process that determines fertility, sexuality, and mood. The regularity of reproductive cycles is closely regulated by neuropeptide- and hormone-mediated communication between neurons in the hypothalamus of the brain and the ovaries. Despite extensive research on the top-down control (hypothalamus-pituitary-ovarian axis, HPO), the precise neuronal targets of ovarian hormonal feedback are not well understood. Gonadotrophin-releasing hormone (GnRH) neurons, the master regulator of the HPO axis, switch between pulsatile and surge release
ePoster · Neuroscience