Differential impact of calorie restriction on memory and mTOR signaling in aging female Wistar rats
Milica Prvulovic, Smilja Todorovic, Desanka Milanovic, Valentina Simeunovic, Andjela Vukojevic, Milena Jovic, Srdjan Sokanovic, Aleksandra Mladenovic · FENS Forum 2024
Calorie restriction (CR) is recognized for its potential to delay age-related changes; however, its effectiveness can vary based on factors such as duration, age, and sex. Implementing CR later in life may not only diminish its protective potential but could also have detrimental effects. Herein, we aimed to investigate the effect of CR on short-term (STM) and long-term (STM) memory and explore the potential role of the mTOR signaling pathway as an underlying molecular mechanism. Female Wistar rats of different ages (adult, middle-aged, and old) were exposed to CR (60% of ad libitum (AL)) to s
ePoster · Neuroscience