A new model mice with cholinergic dysfunction and amyloid pathogenesis for Alzheimer’s disease
Noriyuki Matsukawa, Yo Tsuda, Yuta Madokoro, Kengo Suzuki, Toyohiro Sato, Yuto Uchida, Takashi Saito, Takaomi Saido, Kosei Ojika · FENS Forum 2024
Hippocampal cholinergic neurostimulating peptide (HCNP) was originally discovered from soluble fraction of rat hippocampus, which induces acetylcholine synthesis in the medial septal nucleus. HCNP is aligned at the N-terminal region of 21-kD HCNP precursor protein (HCNP-pp). We reported that HCNP-pp knockout (KO) mice may be an adequate model for cholinergic functional impairment in septo-hippocampal interactions. Here, to encourage drug discovery improving clinical symptom for Alzheimer’s disease we tried to generate a new model mice with cholinergic dysfunction and amyloid pathogenesis. The
ePoster · Neuroscience