Maternal infection during pregnancy induces fetal neuroinflammation, associated with premature oligodendrocyte differentiation and myelin formation, driven by epigenetic changes in oligodendrocyte-specific genes
Rebecca Woods, Harry Potter, Hager Kowash, Jocelyn Glazier, Joanna Neill, Michael Harte, Christopher Murgatroyd, Reinmar Hager · FENS Forum 2024
Introduction: Maternal immune activation (mIA) is a risk factor for schizophrenia. It is hypothesised that mIA-induced fetal neuroinflammation alters neurodevelopment and predisposes offspring to neuropathology. Using our validated mIA model, exposing pregnant rats to the viral mimetic poly(I:C), we have shown that adult offspring exhibit cognitive deficits comparable to those in schizophrenia, and have genomic methylation changes enriched for oligodendrocyte genes.Aims: Examine the relationship between mIA and altered oligodendrocyte development and how these correspond to the onset of adult
ePoster · Neuroscience