Maternal C-reactive protein is associated with white matter alterations in female offspring: A neuroimaging analysis from the FinnBrain Birth Cohort Study
Aaron Barron, Gerard O'Keeffe, Cathal McCarthy, Minna Lukkarinen, Harri Merisaari, Linnea Karlsson, Hasse Karlsson, Jetro Tuulari · FENS Forum 2024
Maternal immune activation (MIA) has been implicated in offspring neurodevelopmental and psychiatric disorders, although it is unknown to what extent MIA affects neurodevelopment in the general population, and whether effects differ by sex. The current study was set within FinnBrain, a prospective birth cohort study based in Turku, Finland. We examined the association between maternal prenatal C-reactive protein (CRP), a commonly used systemic inflammatory marker, and white matter fractional anisotropy (FA) and mean diffusivity (MD) in infant and 5-year-old offspring, using voxel-wise statisti
ePoster · Neuroscience