Coupling between global grey matter and fourth ventricle fMRI signals links with brain clearance in humans
Viktor Neumaier, Moritz Bonhoeffer, Melissa Thalhammer, Julia Schulz, Christine Preibisch, Sibylle Ziegler, Matthias Brendel, Igor Yakushev, Josef Priller, Christian Wachinger, Fabian Bongratz, Markus Karmann, Dennis Hedderich, Felix Brandl, Benedikt Zott, Christian Sorg · FENS Forum 2024
In rodents, the glymphatic system is critically involved in the clearance of brain waste products. In humans, the coupling (i.e., correlation) of resting-state functional MRI signals of global grey matter (gGM-fMRI) and the cerebrospinal fluid signal in the fourth ventricle (CSF-fMRI) is thought to reflect macroscopic glymphatic fluid movement, suggesting relevance for brain clearance. However, direct evidence linking gGM-CSF coupling with brain clearance measures is still missing. We hypothesized that in humans, gGM-CSF coupling is associated with two other measures of the glymphatic system,
ePoster · Neuroscience