Topic: flavored nicotine

The use of electronic cigarettes (e-cigs) has surged in the past 20 years. These devices heat e-liquid containing nicotine and flavor additives into an aerosol form. While studies suggest flavors increase e-cigs use, neurobiological mechanism behind this remain understudied. Therefore, this study aims to understand the neurobiological substrate involved in the rewarding properties of inhaled flavored nicotine. We developed a nicotine-vaping induced conditioned place preference (CPP) protocol to test the rewarding effect of nicotine and flavors in a mouse model. In males, flavored nicotine dose