ATP8A2 controls phosphatidylserine externalisation, structural integrity, and survival in neurons
Adriana Schneider, Alexandra Merkel, Netta Ussyshkin, Lisa Ruff, Paula Zimmer, Daniela Mauceri · FENS Forum 2024
The plasma membrane is characterized by an asymmetric distribution of phospholipids, maintained by three enzyme classes: flippases, floppases, and scramblases. Phosphatidylserine (PS) is confined to the inner leaflet of the plasma membrane under normal conditions, and its externalization has been linked to both apoptotic and non-apoptotic processes within the central nervous system (CNS). Further, neuronal PS exposure can be transient in stressed but viable cells. Thus, interference with PS-triggered phagocytosis of neurons has been suggested to be beneficial in CNS disorders. The mechanism of
ePoster · Neuroscience