Topic: FLNA

Dendritic branching mechanisms are precisely controlled during brain development, as dendritic architecture provides the specificity and capacity of the synaptic input. Integrin receptors on the neuronal membrane are critical regulators of when and where the dendritic arborization will take place during neuronal differentiation. Integrin activity is not solely dictated by external ligand binding – the receptor's shape and function are also fine-tuned by intracellular binding proteins, including actin-binding protein Filamin A (FlnA). By combining in vitro mouse neuronal cultures with genetic a