Topic: fluorescence in situ hybridization (FISH)

The retrosplenial cortex (RSC) and hippocampus support the encoding, storage, and retrieval of different aspects of associative experience. In the hippocampus, learning and updating information about the content details of space triggers long-term depression (LTD) (doi: 10.3389/fnbeh.2022.806356) . Here we used fluorescence in situ hybridization (FISH) explore to what extent this kind of spatial content learning triggers somatic immediate early gene (IEG i.e. Homer1a) expression in the cornus ammonis and RSC, as an indication of active storage of learned experience. Adult rats explored novel s