Topic: fluorescent dopamine sensor

The dopaminergic system facilitates associative learning and motivation by signaling reward expectation and positive or negative valence in selected brain regions. Previous studies measuring somatic and axonal activity suggest a heterogeneous representation of reinforcement signaling by dopaminergic neurons, but it remains unclear how dopamine signals for expectation and valence interact in various brain regions. Here, we used an improved fluorescent dopamine sensor to record dopamine signals associated with reward predictions and valence in eight distinct striatal and non-striatal regions. We