New fluorescent molecular probes for ex vivo assessment of neurodegenerative protein conformational pathology
Lana Blinc, Mateja Drolec Novak, Jerneja Kladnik, Matic Rogan, Damijan Knez, Jernej Mlakar, Ross Jansen-van Vuuren, Janez Košmrlj, Mara Bresjanac · FENS Forum 2024
Therapeutic interventions’ lackluster performance in Alzheimer dementia (AD) may in part be due to the irreversibly advanced stage of the pathological process underlying cognitive decline once the latter is diagnosed. Currently, clinical diagnosis of AD is supported by in vivo molecular imaging of disease-related Aβ and Tau aggregates in the brain, and analysis of cerebrospinal fluid. Positron Emission Tomography, Single Photon Emission Computed Tomography, and Magnetic Resonance imaging are the most common methods used. They are costly, which limits their use in routine screening. We used flu
ePoster · Neuroscience