The mGlu4 positive allosteric modulator foliglurax durably rescues behavioral deficits in three mouse models of autism spectrum disorder
Mathieu Fonteneau, Claire Terrier, Flavie Derouin Tochon, Agathe Brugoux, Delphine Charvin, Julie Le Merrer, Jérôme AJ Becker · FENS Forum 2024
Autism spectrum disorder (ASD) is a complex neurodevelopmental disorder diagnosed in presence of impaired social communication and interaction together with restricted, repetitive repertoire of behaviours, interests, and activities. To date, available medications address comorbidities (e.g. anxiety, irritability, seizures) rather than core symptoms. The aim of the present study was to explore the therapeutic potential of foliglurax, a mGlu4 positive allosteric modulator (PAM), in relieving ASD-like behavioral features in the well validated genetic Shank3B knockout mouse model, and to assess ho
ePoster · Neuroscience