Alterations in dopaminergic innervation and receptor expression in mouse models and patients with focal cortical dysplasia
Norisa Meli, Albert Becker, Sandra Blaess · FENS Forum 2024
Focal Cortical Dysplasia IIB (FCDIIB) represents a large variety of cortical malformations associated with abnormal cortical layering and appearance of dysmorphic neuronal elements, often occurring in the frontal cortex. FCDIIB is a common cause of pharmaco-resistant epilepsies and altered local neuronal activity has been reported in human FCDIIB tissue samples. Local cortical microcircuits are extensively modulated by monoaminergic axonal projections arising from the brain stem. Previous analysis of monoaminergic modulatory inputs in human FCDIIB biopsies suggested altered density and distrib
ePoster · Neuroscience