High-density EEG in the pilocarpine model of temporal lobe epilepsy: A power spectrum analysis of tonic-clonic seizures
Beatrice Casadei Garofani, Arianna Capodiferro, Stefania Bartoletti, Federica Raimondi, Elisa Ren, Daniela Gandolfi, Giulia Curia · FENS Forum 2024
Temporal lobe epilepsy (TLE) is characterized by spontaneous recurrent seizures poorly controlled by antiseizure medications in over 30% of patients. The current study aims to investigate the most epileptogenic areas in a TLE animal model using high-density EEG.Sprague Dawley male rats were injected intraperitoneally with pilocarpine to induce the status epilepticus (SE) terminated 30 minutes later by ketamine/diazepam. Two weeks later animals were implanted with epidural electrodes in the frontal cortex and depth electrodes in several temporal areas. Video-EEG recordings (24h, >3 days/week
ePoster · Neuroscience