Different mechanisms underlie compulsive alcohol self-administration in male and female rats
Esi Domi, Sanne Toivainen, Li Xu, Francesco Gobbo, Andrea Della Valle, Andrea Coppola, Markus Heilig · FENS Forum 2024
Sex is an important factor in the progression and treatment of alcohol addiction, and therapeutic approaches may have to be tailored to potential sex differences. This highlights the importance of understanding sex differences in behaviors that reflect key elements of clinical alcohol addiction, such as compulsive use.Large populations of genetically heterogeneous male and female Wistar rats were tested in an established model of compulsive alcohol self-administration, operationalized as alcohol responding despite contingent foot shock punishment. We also tested baseline alcohol self-administr
ePoster · Neuroscience