Activation of parvalbumin+ interneurons in orbitofrontal cortex leads to higher functional connectivity, increased cerebral blood volume, and social dysregulation
Elmira Khatamsaz, Tudor M. Ionescu, Franziska Stoller, Katja Szkudlarek, Bastian Hengerer · FENS Forum 2024
Clinical studies in PRISM1 (Psychiatric Ratings using Intermediate Stratified Markers) indicated that social dysfunction is transdiagnostically associated with default mode network dysconnectivity. Low social functioning groups exhibit decreased DTI fractional anisotropy in backbone structures of the DMN such as forceps minor, the interhemispheric connection of the orbitofrontal cortices (OFC). This study aims to back-translate these data by understanding the role of parvalbumin interneurons (PV+) in OFC.We studied the effect PV+ interneuron activation on social behaviors in mice by using an a
ePoster · Neuroscience