FOXG1 controls cellular function and tissue architecture in 2D neural rosettes and 3D cerebral organoid models of epilepsy
Oliver Davis, Dwaipayan Adhya, Wai Kit Chan, John Mason, Andras Lakatos, Srinjan Basu · FENS Forum 2024
FOXG1 is a transcription factor essential for brain development. Mutations in FOXG1 perturb forebrain development and are commonly associated with neurodevelopmental conditions such as autism and epilepsy. These conditions often also co-occur and preliminary studies have suggested a convergent aetiology. Thus studying the biological functions of FOXG1 and providing mechanistic insight into its functions can better reveal the molecular and cellular aetiology of these conditions. This will help us accelerate biomarker discovery and therapeutic strategies for epilepsy in individuals with or witho
ePoster · Neuroscience