Topic: formic acid

We investigate the link between the gut microbiome and cognitive decline in Alzheimer’s disease by identifying microbial metabolites associated with (compromised) brain health and examining metabolite changes in individuals who progress from a healthy state (NL) to mild cognitive impairment (MCI) and/or Alzheimer’s disease (AD).A dataset containing representative microbial metabolites in serum was obtained from the Alzheimer’s Disease Neuroimaging Initiative. A total of 104 metabolites were analyzed. These were collected over six years from 757 individuals. Kruskal-Wallis test was employed to