Uncovering the implicit dynamics of the spontaneous cortical activity transition to epilepsy using phase space reconstruction (PSR)
Alexia Karantana, Kostas Andrikos, Nikos Vasilopoulos, Michael Vinos, Irini Skaliora · FENS Forum 2024
The ability to predict the onset of epileptic activity remains an important goal of preclinical neuroscience. Here, we investigate the transition from spontaneous Up/Down states, considered the default cortex network activity, to the hypersynchronous epileptiform state. We recorded local field potential (LFP) activity in acute cortical slices of wild-type and transgenic mouse models and used various seizure-induction protocols. The PSR method, a powerful tool in the field of nonlinear dynamical systems, has been used to gain insights of this dynamic complex phenomenon. It has been shown that s
ePoster · Neuroscience