ePoster · Neuroscience
Eye movement abnormalities as early biomarkers of Alzheimer’s disease
Andrea Zangrossi, Stefano Mozzetta, Valentina Carlucci, Giovanni Zorzi, Cinzia Bussè, Anna Chiara Cagnin, Maurizio Corbetta · FENS Forum 2024
The diagnosis of Alzheimer's disease (AD) typically occurs after the onset of cognitive symptoms. Consequently, the global challenge around the world is to identify early and easily accessible biomarkers. Intriguingly, certain brainstem structures, such as the Superior Colliculus (SC), which plays a pivotal role in fixation maintenance and saccade programming, exhibit neurofibrillary changes sooner than cortical regions (Uematsu et al., 2018) and is susceptible to tau pathology and neuronal loss in AD patients. Accordingly, eye movement abnormalities associated with AD are often observed durin