Compositionality of latent dynamics over multiple timescales underlies whole-brain neural activity during spontaneous behavior
Evan Vickers, Scott Linderman, Michael Johnson, Stefano Recanatesi, David McCormick, Luca Mazzucato · COSYNE 2025
Neural activity and behavior in awake animals reflect the interaction between multiple fast processes, such as movements, and slow processes, including arousal, neuromodulation, and learning. A variety of experimental and modeling approaches have successfully tackled single aspects along this spectrum, but a comprehensive multi-scale framework is lacking. To address this challenge, we developed two-photon (2p) mesoscope assays to record neural activity at single-cell resolution from the dorsal and lateral cortex of freely running mice during behavior. We found that whole-brain single-cell dyna
ePoster · Neuroscience