Differential distribution of key regulatory ion channels in excitatory synapses of the epileptic human brain revealed by freeze-fracture replica analysis
Walter Kaufmann, Alessandro Venturino, David Kleindienst, Karl Rössler, Thomas Czech, David Vandael, Maren Engelhardt, Sandra Siegert, Ryuichi Shigemoto · FENS Forum 2024
Temporal lobe epilepsy (TLE) is the most common form of focal epilepsy. Though available anticonvulsants achieve a full seizure control for two-thirds of the TLE patients, one third does not respond sufficiently to these drugs and resection of the seizure area is the best possible treatment for them. One way to improve this is to identify key regulatory ion channels in excitatory synaptic function. Here, we investigated the ultrastructural localization of I) P/Q-type voltage-gated calcium channels (Cav2.1) at the presynaptic site triggering vesicle release and II) AMPA receptors mediating the
ePoster · Neuroscience