Topic: frequency tuning

A growing understanding of cortical interneuron circuits has highlighted the role of specific inhibitory interneurons in shaping sensory tuning and discrimination acuity. In auditory cortex, neuron-derived neurotrophic factor-expressing interneurons (NDNF-INs) reside in layer 1 where they receive tonotopic projections from the auditory thalamus. In turn, they inhibit the dendrites of out-of-column excitatory pyramidal neurons while disinhibiting within-column neurons via descending projections to parvalbumin-positive interneurons. This circuitry suggests that NDNF-INs are well-poised to modula