KIF5B plays important roles in dendritic spine plasticity and dendritic localization of PSD95 and FMRP in the mouse cortex in vivo
Cora Sau Wan Lai, Albert Hiu Ka Fok, Yuhua Huang, Beth Wing Lam So, Qiyu Zheng, Chun Sing Carlos Tse, Xiaoyang Li, Kenneth Kin-Yip Wong, Jiandong Huang, Kwok-On Lai · FENS Forum 2024
Kinesin 1 (KIF5) is one of the major types of motor proteins that transport synaptic proteins and mRNAs to dendrites, but their function in dendritic transport of neurons in vivo remains undefined. Using in vivo two-photon longitudinal imaging, we found that mice with conditional knockout of kif5b (KIF5B cKO) in CaMKIIα-Cre expressing neurons showed heightened turnover and lower stability of dendritic spines in L2/3 pyramidal neurons in the frontal association cortex. The increase of dendritic spine instability was accompanied with less postsynaptic density 95 (PSD95) acquisition in dendritic
ePoster · Neuroscience